Question:
Why not mention the newsgroup, then we can flame them too 
. Dave S. They already have been invaded by the flamers from this group. d
They’ve not been invaded by ME!!!! 
)) Beav
Response:
Please note Thios person is a known troll on this newdgroup. according to them everything right or wrong in the universe is caused by too much or too little iron. Please turn on your repelling electromagnets!! " The greatest pleasure in life is doing what people say you cannot do"
An ‘iron’ bar placed between the eyes might be of more use in getting rid of him -(( — Mark Brown
Response:
Why not mention the newsgroup, then we can flame them too . Dave S.
They already have been invaded by the flamers from this group. d
Response:
It creates the illusion of dealing with your diabetes. I used to feel like I was treating my diabetes if I read the newsgroup every day. After having been away for a year or so, I am shocked to see how silly the fights are How would you compare your blood glucose control now to a year or so ago? For science sake .. It’s much better. I don’t know that that has anything to do with stopping reading the newsgroup. Probably more likely had something to do with getting a new endo
Thats sort of a small study then.. before when your glucose was fluctuating .. you enjoyed a good scrap.. but NOW since it is in control.. you can take it or leave it ..? Who loves ya. Tom — Jesus was a Vegetarian! http://www.nucleus.com/watchman Moses was a Mystic! http://www.nucleus.com/watchman/light.html
Response:
It creates the illusion of dealing with your diabetes. I used to feel like I was treating my diabetes if I read the newsgroup every day. After having been away for a year or so, I am shocked to see how silly the fights are How would you compare your blood glucose control now to a year or so ago? For science sake ..
It’s much better. I don’t know that that has anything to do with stopping reading the newsgroup. Probably more likely had something to do with getting a new endo
Response:
It creates the illusion of dealing with your diabetes. I used to feel like I was treating my diabetes if I read the newsgroup every day. After having been away for a year or so, I am shocked to see how silly the fights are
How would you compare your blood glucose control now to a year or so ago? For science sake .. Who loves ya. Tom — Jesus was a Vegetarian! http://www.nucleus.com/watchman Moses was a Mystic! http://www.nucleus.com/watchman/light.html
Response:
When there are NUMEROUS articles out of Medline which speak to this fact? There are are there? Somehow I don’t think so.
Yeh .. why don’t YOU become a moderator and you could REFUSE to post articles to the group based on just what you THINK.. Sort of like these articles .. refused by the moderators of these groups .. eh .. Sci.med.aids .. J Clin Virol 2001 Feb;20(3):111-5 Iron status and the outcome of HIV infection: an overview. Gordeuk VR, Delanghe JR, Langlois MR, Boelaert JR Center for Sickle Cell Disease and Department of Medicine, Howard University College of Medicine, 20059, Washington, DC, USA [Medline record in process] Background: Theoretical considerations and experiments in the laboratory suggest that excessive iron stores may have an adverse effect on immunity. If so, high iron stores might be especially a problem in patients with human immunodeficiency virus (HIV) infection. Objective and study design: Review published clinical studies that provide information regarding the effect of iron status on the outcome of HIV infection. Results: Four clinical observations have provided some perspective on the effect of iron status on the outcome of HIV-1 infection. First, in a restrospective study of HIV-positive thalassemia major patients, the rate of progression of HIV disease was significantly faster in patients with lower doses of desferrioxamine and higher serum ferritin concentrations. Second, the inadvertent simultaneous administration of low doses of oral iron with dapsone for the prophylaxis of Pneumocystis carinii pneumonia in HIV-positive patients may have been associated with excess mortality. Third, a study of haptoglobin polymorphisms in HIV-positive subjects indicated that the haptoglobin 2-2 polymorphism is associated with higher iron stores and shortened survival as compared with the haptoglobin 1-1 or 2-1 phenotypes. Fourth, a retrospective study of bone marrow macrophage iron in HIV-positive patients suggested that survival is shorter with high iron stores. Conclusion: These four observations raise the possibility that high iron status may adversely influence the outcome of HIV-1 infection. PMID: 11166657, UI: 21112136 Cystic-l .. Genet Test 1998;2(1):85-8 Is the hemochromatosis gene a modifier locus for cystic fibrosis? Rohlfs EM, Shaheen NJ, Silverman LM Department of Pathology & Laboratory Medicine, University of North Carolina, Chapel Hill 27599, USA. The variable clinical manifestations of cystic fibrosis (CF) suggest the influence of modifier genes. For example, meconium ileus is present in approximately 10-15% of neonates with cystic fibrosis; however, the genetic and, or environmental factors that determine whether an individual will develop this complication have not been determined. We propose the HFE gene as a candidate modifier locus for CF based on (1) the suggestion of an association between the HLA loci and CF phenotypes; (2) the location of the HFE gene near the HLA loci and; (3) the similarity between the gastrointestinal manifestations of hereditary hemochromatosis and CF. We have determined the frequency of the C282Y and H63D mutations in a group of 89 CF patients who were homozygous for delta F508 and for whom meconium ileus status was known. The carrier frequency of C282Y among the CF patients with meconium ileus was significantly different from that of our unaffected control group (19.4% versus 7.7%). However, the difference between the meconium ileus and the nonmeconium ileus groups was not significant (19.4% versus 10.3%). There was no difference in the frequency of the H63D among the three groups that were studied. These data are suggestive of a relationship between the development of meconium ileus or other gastrointestinal diseases in CF and the HFE gene. Further study of a larger group of patients is warranted. PMID: 10464603, UI: 99393869 and as this thread speaks to .. is ONLY helping .. yourself.. which would make you an abusive irresponsible selfish person .. You’re not making a whole lot of sense now watchprick, are you feeling Ok?
Let me explain it to you since you seem to have a hard time understanding simple things .. Being abusive balances YOUR blood glucose PROVEN in the ‘tribe’. ONLY helps YOU = selfish .. Badmouthing PERTINENT information which may stay someone from losing their feet or going blind = irresponsible Beavis = abusive selfish irresponsible abusive person Chromosome 6 is the one which is iron overload .. notice diabetes.. Right under .. D .. dyslexia .. and if I remember correctly THAT would be someones problem on this list .. Yeah, YOURS. Have you ever read one of your posts? They read like some 2nd grader wrote them. Rambling, wandering and making little, is any, sense.
ONLY .. TO .. a person with a 2nd grade education .. Genetic disorders associated with Chromosome 6:
Those with these disorders put up their hands and remember .. I .. remember WHO you are .. Genetic disorders associated with Chromosome 6: Adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency Ankylosing spondylitis Atrial septal defect, secundum type Bare lymphocyte syndrome, type I, due to TAP2 deficiency Beryllium disease, chronic, susceptibility to Breast cancer Butterfly dystrophy, retinal C2 deficiency C4 deficiency Coronary artery disease, susceptibility to Diabetes mellitus, insulin-dependent, neonatal Diabetes mellitus, insulin-dependent-1 Dyslexia, specific, 2 Dysplasminogenemic thrombophilia Epilepsy, juvenile myoclonic Estrogen resistance Factor XIIIA deficiency Hemochromatosis Immotile cilia syndrome Laryngeal adductor paralysis Leukemia, acute nonlymphocytic Macular dystrophy Macular dystrophy, North Carolina type Maple syrup urine disease, type 3 Metaphyseal chondrodysplasia, Schmid type Methylmalonicaciduria, mutase deficiency type Muscular dystrophy, congenital, merosin-negative Ocular albinism, autosomal recessive Orofacial cleft Ovarian cancer, serous Paget disease of bone Pelviureteric junction obstruction Plasminogen deficiency, types I and II Plasminogen Tochigi disease Polycystic kidney disease, autosomal recessive Ragweed sensitivity Renal glucosuria Retinal cone dystrophy-1 Retinitis pigmentosa, digenic Retinitis pigmentosa, peripherin-related Retinitis pigmentosa-14 Retinitis punctata albescens Salla disease Sialidosis Spinocerebellar ataxia-1 Stargardt disease 3 Stickler syndrome, type 2(2) Who loves ya. Tom — Jesus was a Vegetarian! http://www.nucleus.com/watchman Moses was a Mystic! http://www.nucleus.com/watchman/light.html
Response:
Iron! I knew it couldn’t last So what good to this world do YOU think you are .. there ..
Beav? "there" what? As for what good do I think I am, well for one I jump all over you when you post your drivel. That alone is worth at least 100 Brownie points. Badmouthing posts about iron beng involved in diabetes?
You think I shouldn’t?? Yeah, well you would, but who gives a flying what YOU think? When there are NUMEROUS articles out of Medline which speak to this fact?
There are are there? Somehow I don’t think so. When one works AGAINST something .. it is a whole lot different than taking no stance at all .. You BECOME the evil ..
And you’re the messiah?? But I think you rather enjoy the handle of irresponsible due to the fact you have proven to be no value at all in the time I have subscribed to this list ..
Well thank fuck I’ve been of no value to you. That would’ve REALLY pissed on my parade. Other than being abusive
You’ve not seen abusive yet. and as this thread speaks to .. is ONLY helping .. yourself.. which would make you an abusive irresponsible selfish person ..
You’re not making a whole lot of sense now watchprick, are you feeling Ok? I suppose you can live with it ..
Happily. By what I’ve seen .. anyhow .. Chromosome 6 is the one which is iron overload .. notice diabetes.. Right under .. D .. dyslexia .. and if I remember correctly THAT would be someones problem on this list ..
Yeah, YOURS. Have you ever read one of your posts? They read like some 2nd grader wrote them. Rambling, wandering and making little, is any, sense. Genetic disorders associated with Chromosome 6:
You forgot earache! <snipped all the rest
Response:
By the way, don’t know if you know this, but I’ve seen this newsgroup being discussed on other newsgroups. The upshot of the discussion was that if you like Jerry Springer, you should tune in to MHD.
How odd, I find MHD one of the mildest groups. Perhaps the other groups you mention are of the afternoon tea variety.
Response:
Could it be that the behavior on this newsgroup, thought to be unusually confrontational, combative, and rancorous (just showing off the vocab—these are all pretty much synonymous), serves to keep its participants healthy?
If I recall correctly, there were studies which showed the degree of OCD and asinine behaviour to friends and relatives in diabetes was correlated with good BG control (i.e. being inflexible and unyielding). There have also been numerous studies which show long term chronic illnesses lead to dissociation from one’s body (regarding one’s body as an external thing rather than as "you"). I would assume most long term diabetics are not "optimistic" and if they are overly optimistic they end up dead before too long. I have seen this in many cases… where "normal" optimism / happiness levels become fatal in a chronic condition. The optimism that might lead X into a bad marriage in health, leads X into a dialysis unit when X is diabetic. By the way, don’t know if you know this, but I’ve seen this newsgroup being discussed on other newsgroups. The upshot of the discussion was that if you like Jerry Springer, you should tune in to MHD.
Why not mention the newsgroup, then we can flame them too . Dave S.
Response:
– Hide quoted text — Show quoted text – Watchman, I don’t understand your comments about the tribe. Offended Lurker was wondering aloud whether flaming and anger lead to depression, loss of appetite and better blood sugar control. You stated that his thesis was proven by the angry tribe that raised their blood glucose level. Your evidence seems to disprove, not prove, his thesis. Please explain. I should have said .. ‘balances’ the blood sugar levels .. brings them into the ‘norm’ ..
You should’ve said LOTS of things, but you only ever do AFTER you’ve been sussed. You’re a waste of space and fortunately everyone knows it. There’s not ONE thing you’ve ever posted on this group that could help any single diabetic. Beav
Response:
Could it be that all the hard feelings, the obsessive flaming and counter flaming keep us agitated, depressed, and so queasy that we easily keep our appetites under control?
An interesting idea, but I don’t think so. It seems to me to be nothing more than an opportunity to vent one’s rage over feeling powerless. There are no consequences to "venting" here. You don’t get fired, your girlfriend doesn’t leave you, your friends don’t shun you. Someone you don’t know might type a couple of nasty words on a screen. Big deal. You can even get off on upsetting so many people in so many foreign lands. Power. Wow. Could it be that the behavior on this newsgroup, thought to be unusually confrontational, combative, and rancorous (just showing off the vocab—these are all pretty much synonymous), serves to keep its participants healthy?
It creates the illusion of dealing with your diabetes. I used to feel like I was treating my diabetes if I read the newsgroup every day. After having been away for a year or so, I am shocked to see how silly the fights are (and I used to be one of the first to start swinging, believe me) and how much crap is spread out around here, plain ole misinformation masked as knowledge. And I’m not necessarily talking about the spammers — I’m also talking about "information" from some of the so-called experts in the group. I don’t know how you go about sorting it out without playing God yourself, but it’s kind of scary. By the way, don’t know if you know this, but I’ve seen this newsgroup being discussed on other newsgroups. The upshot of the discussion was that if you like Jerry Springer, you should tune in to MHD.
That may be true, but I say go to any screenwriters group if you want to see serious, serious hostility!
Response:
Please note Thios person is a known troll on this newdgroup. according to them everything right or wrong in the universe is caused by too much or too little iron. Please turn on your repelling electromagnets!! " The greatest pleasure in life is doing what people say you cannot do"
Response:
Watchman, I don’t understand your comments about the tribe. Offended Lurker was wondering aloud whether flaming and anger lead to depression, loss of appetite and better blood sugar control. You stated that his thesis was proven by the angry tribe that raised their blood glucose level. Your evidence seems to disprove, not prove, his thesis. Please explain.
I should have said .. ‘balances’ the blood sugar levels .. brings them into the ‘norm’ .. Who loves ya. Tom – Hide quoted text — Show quoted text – made me stop and think. Could the personal attacks on this NG, which would at first appear to be harmful, actually have some positive effect? Could it be that all the hard feelings, the obsessive flaming and counter flaming keep us agitated, depressed, and so queasy that we easily keep our appetites under control? Could it be that the behavior on this newsgroup, thought to be unusually confrontational, combative, and rancorous (just showing off the vocab—these are all pretty much synonymous), serves to keep its participants healthy? By the way, don’t know if you know this, but I’ve seen this newsgroup being discussed on other newsgroups. The upshot of the discussion was that if you like Jerry Springer, you should tune in to MHD. Research has already proven it .. I spoke to it before where researchers found a tribe in the mountains who would fly off the handle at the slightest little thing .. They narrowed the problem down to a blood sugar problem.. The anger would raise their blood sugar levels .. Over on the arthritis list they are now ‘in a huddle’ discussing how to mass email my ISP .. to have me pulled from my server .. They have nothing ‘on me’ to do it ..but they are now pulling postings out of the groups to mass email with them .. and I suppose a couple of the scraps out of this group are going out .. All because I again refuse to back down to threats and abuse .. and the ‘religious’ fanatics who are attacking me because of my sig .. Sulpha drugs .. used by EVERYONE and doing great things in those with arthritis .. are the latest .. They found after all these years they work by chelating the iron in the body .. You would think they might ‘thank me’ for ‘pointing it out’ but instead these guys are crying ‘blue bloody murder’ and writing fake abuse letters to my server who has already been inundated with letters over the past few months .. Hell these guys have been yelling the f world at me for awhile .. I simply say ‘why would you try to have a guys ISP pull him when he places articles like these’ .. And I think it is definitely the religious fanatics who are really going nuts .. cause THEY know He was no vegetarian and the fact that what I say about iron and arthritis being TRUE comes SECOND to that.. even IF .. kids are being saved years of relentless pain .. Now that is why I try to stay away from the religious people .. they simply seem not to care who they ‘hurt’ just that they make sure THEY are in charge .. Scary stuff … TEKTRAN IRON DEPOSITION IN THE JOINTS OF CHILDREN WITH JUVENILE RHEUMATOID ARTHRITIS Author(s): SHYPAILO ROMAN J ELLIS KENNETH J PEREZ MARIA ABRAMS STEVEN A Interpretive Summary: We wanted to develop an accurate and noninvasive way of determining the amount of iron deposited in the joints of patients with juvenile rheumatoid arthritis. Children with JRA often develop excess iron in their joints, so doctors need a way of monitoring the iron level, particularly when prescribing iron supplements for the common problem of anemia. However, the only method currently available is to take a biopsy. We adapted a machine called a gamma counter to measure the iron in eight patients’ joints after giving them an iron isotope by vein. Then we compared the results with the total amount of iron in their bodies, measured by a whole-body counter. We found that we had developed an accurate new way of measuring iron in these patients’ joints. We also found that six of the eight subjects had excess uptake of the iron isotope in their joints. That provided a signal that a preponderance of JRA patients are prone to have this problem, and clinicians should take special care to monitor them for it. Moreover, this is the first time a noninvasive way of performing this measurement has been available. Keywords: energy reproduction growth body composition women infants children water potassium bioelectrical impedance conductance bromide space lactating iron adipose tissue lipid motabolism beta-adrenergic receptor cell culture neutron activation nitrogen carbon calcium sodium chlorine phosphorus hormonal changes differentiation adipocyte hnrim021125 Contact: USDA/ARS CHILDREN’S NUTR 1100 BATES ST. HOUSTON TX 77030 FAX: (713)798-7130 TEKTRAN United States Department of Agriculture Agricultural Research Service Updated: 1999-01-16 It seems the idea of the treatment of iron has been around for a long time but the mode of opertion of these drugs have only been coming to light in the last decade.. And it seems iron .. is the mode of operation .. or more like .. chelation of iron .. Orv Hetil 1991 Jun 16;132(24):1317-21 [New salicylic acid derivatives in the treatment of inflammatory intestinal diseases]. [Article in Hungarian] Kovacs A Fovarosi Tanacs Balassa Janos Korhaz-Rendelointezet I. Belyogyaszati ostaly. Drug therapy for inflammatory bowel disease was limited for many years to sulfasalazine and some corticosteroids. Since the discovery that 5-aminosalicylic acid (5-ASA) is the active moiety of sulphasalazine in the treatment of chronic inflammatory bowel disease, several new drugs have been developed. These consist either of slow- or delayed-release formulations of plaint 5-ASA (mesalazin) or sulpha-free azo-compounds of 5-ASA. The varying bioavailabilities of the different formulations and compounds make it possible to use them alternatively in different clinical situations. A review of the literature is given and suggestions as to how the new drugs can be used in different diseases. Publication Types: * Review * Review, tutorial PMID: 1677465, UI: 91312731 Save the above report in [Macintosh] [Text] format Order documents on this page through Loansome Doc Dig Dis Sci 1992 Sep;37(9):1383-9 Prooxidant properties of 5-aminosalicylic acid. Possible mechanism for its adverse side effects. Grisham MB, Ware K, Marshall S, Yamada T, Sandhu IS Department of Physiology and Biophysics, Louisiana State University Medical Center, Shreveport 71130. There is a growing body of experimental and clinical evidence to suggest that oral or rectal administration of 5-ASA or 5-ASA conjugates is associated with significant adverse side effects including pancreatitis, hepatitis, and renal toxicity. The objective of this study was to assess the ability of 5-ASA to interact with low-molecular-weight iron to yield oxygen-derived free radicals and to determine whether these oxidants could damage model biological compounds. We found that 5-ASA was very effective at chelating ferric iron (Fe3+), and it rapidly reduced Fe3+ to the ferrous form (Fe2+). Addition of the 5-ASA/Fe2+ chelate to solutions containing polyunsaturated fatty acids or deoxyribose resulted in lipid peroxidation and oxidative carbohydrate degradation, respectively. These results are consistent with the formation of the highly reactive (and cytotoxic) hydroxyl radical. Formation of this free radical species was confirmed by the ability of hydroxyl radical scavengers (dimethyl sulfoxide, dimethyl thiourea) to inhibit the 5-ASA/Fe-mediated oxidative reactions. Maximum hydroxyl radical formation was achieved at a 5-ASA-to-Fe3+ ratio of 1.0 (20 microM 5-ASA and 20 microM Fe3+). Increasing this ratio significantly inhibited OH. formation with a concomitant reduction in lipid peroxidation and deoxyribose degradation. Finally, we demonstrated that 5-ASA promotes the reductive release of Fe3+ from ferritin. Data obtained in this study suggest that 5-ASA may, under certain conditions, promote the formation of potentially injurious free radical species. These oxidative reactions may contribute to some of the adverse side effects known to be associated with the newer preparations of 5-ASA. PMID: 1505290, UI: 92371110 Med
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Response:
Iron! I knew it couldn’t last
So what good to this world do YOU think you are .. there .. Beav? Badmouthing posts about iron being involved in diabetes? When there are NUMEROUS articles out of Medline which speak to this fact? When one works AGAINST something .. it is a whole lot different than taking no stance at all .. You BECOME the evil .. But I think you rather enjoy the handle of irresponsible due to the fact you have proven to be no value at all in the time I have subscribed to this list .. Other than being abusive and as this thread speaks to .. is ONLY helping .. yourself.. which would make you an abusive irresponsible selfish person .. I suppose you can live with it .. By what I’ve seen .. anyhow .. Chromosome 6 is the one which is iron overload .. notice diabetes.. Right under .. D .. dyslexia .. and if I remember correctly THAT would be someones problem on this list .. Genetic disorders associated with Chromosome 6: Adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency Ankylosing spondylitis Atrial septal defect, secundum type Bare lymphocyte syndrome, type I, due to TAP2 deficiency Beryllium disease, chronic, susceptibility to Breast cancer Butterfly dystrophy, retinal C2 deficiency C4 deficiency Coronary artery disease, susceptibility to Diabetes mellitus, insulin-dependent, neonatal Diabetes mellitus, insulin-dependent-1 Dyslexia, specific, 2 Dysplasminogenemic thrombophilia Epilepsy, juvenile myoclonic Estrogen resistance Factor XIIIA deficiency Hemochromatosis Immotile cilia syndrome Laryngeal adductor paralysis Leukemia, acute nonlymphocytic Macular dystrophy Macular dystrophy, North Carolina type Maple syrup urine disease, type 3 Metaphyseal chondrodysplasia, Schmid type Methylmalonicaciduria, mutase deficiency type Muscular dystrophy, congenital, merosin-negative Ocular albinism, autosomal recessive Orofacial cleft Ovarian cancer, serous Paget disease of bone Pelviureteric junction obstruction Plasminogen deficiency, types I and II Plasminogen Tochigi disease Polycystic kidney disease, autosomal recessive Ragweed sensitivity Renal glucosuria Retinal cone dystrophy-1 Retinitis pigmentosa, digenic Retinitis pigmentosa, peripherin-related Retinitis pigmentosa-14 Retinitis punctata albescens Salla disease Sialidosis Spinocerebellar ataxia-1 Stargardt disease 3 Stickler syndrome, type 2(2) — Jesus was a Vegetarian! http://www.nucleus.com/watchman Moses was a Mystic! http://www.nucleus.com/watchman/light.html
Response:
Watchman, I don’t understand your comments about the tribe. Offended Lurker was wondering aloud whether flaming and anger lead to depression, loss of appetite and better blood sugar control. You stated that his thesis was proven by the angry tribe that raised their blood glucose level. Your evidence seems to disprove, not prove, his thesis. Please explain.
– Hide quoted text — Show quoted text – made me stop and think. Could the personal attacks on this NG, which would at first appear to be harmful, actually have some positive effect? Could it be that all the hard feelings, the obsessive flaming and counter flaming keep us agitated, depressed, and so queasy that we easily keep our appetites under control? Could it be that the behavior on this newsgroup, thought to be unusually confrontational, combative, and rancorous (just showing off the vocab—these are all pretty much synonymous), serves to keep its participants healthy? By the way, don’t know if you know this, but I’ve seen this newsgroup being discussed on other newsgroups. The upshot of the discussion was that if you like Jerry Springer, you should tune in to MHD. Research has already proven it .. I spoke to it before where researchers found a tribe in the mountains who would fly off the handle at the slightest little thing .. They narrowed the problem down to a blood sugar problem.. The anger would raise their blood sugar levels .. Over on the arthritis list they are now ‘in a huddle’ discussing how to mass email my ISP .. to have me pulled from my server .. They have nothing ‘on me’ to do it ..but they are now pulling postings out of the groups to mass email with them .. and I suppose a couple of the scraps out of this group are going out .. All because I again refuse to back down to threats and abuse .. and the ‘religious’ fanatics who are attacking me because of my sig .. Sulpha drugs .. used by EVERYONE and doing great things in those with arthritis .. are the latest .. They found after all these years they work by chelating the iron in the body .. You would think they might ‘thank me’ for ‘pointing it out’ but instead these guys are crying ‘blue bloody murder’ and writing fake abuse letters to my server who has already been inundated with letters over the past few months .. Hell these guys have been yelling the f world at me for awhile .. I simply say ‘why would you try to have a guys ISP pull him when he places articles like these’ .. And I think it is definitely the religious fanatics who are really going nuts .. cause THEY know He was no vegetarian and the fact that what I say about iron and arthritis being TRUE comes SECOND to that.. even IF .. kids are being saved years of relentless pain .. Now that is why I try to stay away from the religious people .. they simply seem not to care who they ‘hurt’ just that they make sure THEY are in charge .. Scary stuff … TEKTRAN IRON DEPOSITION IN THE JOINTS OF CHILDREN WITH JUVENILE RHEUMATOID ARTHRITIS Author(s): SHYPAILO ROMAN J ELLIS KENNETH J PEREZ MARIA ABRAMS STEVEN A Interpretive Summary: We wanted to develop an accurate and noninvasive way of determining the amount of iron deposited in the joints of patients with juvenile rheumatoid arthritis. Children with JRA often develop excess iron in their joints, so doctors need a way of monitoring the iron level, particularly when prescribing iron supplements for the common problem of anemia. However, the only method currently available is to take a biopsy. We adapted a machine called a gamma counter to measure the iron in eight patients’ joints after giving them an iron isotope by vein. Then we compared the results with the total amount of iron in their bodies, measured by a whole-body counter. We found that we had developed an accurate new way of measuring iron in these patients’ joints. We also found that six of the eight subjects had excess uptake of the iron isotope in their joints. That provided a signal that a preponderance of JRA patients are prone to have this problem, and clinicians should take special care to monitor them for it. Moreover, this is the first time a noninvasive way of performing this measurement has been available. Keywords: energy reproduction growth body composition women infants children water potassium bioelectrical impedance conductance bromide space lactating iron adipose tissue lipid motabolism beta-adrenergic receptor cell culture neutron activation nitrogen carbon calcium sodium chlorine phosphorus hormonal changes differentiation adipocyte hnrim021125 Contact: USDA/ARS CHILDREN’S NUTR 1100 BATES ST. HOUSTON TX 77030 FAX: (713)798-7130 TEKTRAN United States Department of Agriculture Agricultural Research Service Updated: 1999-01-16 It seems the idea of the treatment of iron has been around for a long time but the mode of opertion of these drugs have only been coming to light in the last decade.. And it seems iron .. is the mode of operation .. or more like .. chelation of iron .. Orv Hetil 1991 Jun 16;132(24):1317-21 [New salicylic acid derivatives in the treatment of inflammatory intestinal diseases]. [Article in Hungarian] Kovacs A Fovarosi Tanacs Balassa Janos Korhaz-Rendelointezet I. Belyogyaszati ostaly. Drug therapy for inflammatory bowel disease was limited for many years to sulfasalazine and some corticosteroids. Since the discovery that 5-aminosalicylic acid (5-ASA) is the active moiety of sulphasalazine in the treatment of chronic inflammatory bowel disease, several new drugs have been developed. These consist either of slow- or delayed-release formulations of plaint 5-ASA (mesalazin) or sulpha-free azo-compounds of 5-ASA. The varying bioavailabilities of the different formulations and compounds make it possible to use them alternatively in different clinical situations. A review of the literature is given and suggestions as to how the new drugs can be used in different diseases. Publication Types: * Review * Review, tutorial PMID: 1677465, UI: 91312731 Save the above report in [Macintosh] [Text] format Order documents on this page through Loansome Doc Dig Dis Sci 1992 Sep;37(9):1383-9 Prooxidant properties of 5-aminosalicylic acid. Possible mechanism for its adverse side effects. Grisham MB, Ware K, Marshall S, Yamada T, Sandhu IS Department of Physiology and Biophysics, Louisiana State University Medical Center, Shreveport 71130. There is a growing body of experimental and clinical evidence to suggest that oral or rectal administration of 5-ASA or 5-ASA conjugates is associated with significant adverse side effects including pancreatitis, hepatitis, and renal toxicity. The objective of this study was to assess the ability of 5-ASA to interact with low-molecular-weight iron to yield oxygen-derived free radicals and to determine whether these oxidants could damage model biological compounds. We found that 5-ASA was very effective at chelating ferric iron (Fe3+), and it rapidly reduced Fe3+ to the ferrous form (Fe2+). Addition of the 5-ASA/Fe2+ chelate to solutions containing polyunsaturated fatty acids or deoxyribose resulted in lipid peroxidation and oxidative carbohydrate degradation, respectively. These results are consistent with the formation of the highly reactive (and cytotoxic) hydroxyl radical. Formation of this free radical species was confirmed by the ability of hydroxyl radical scavengers (dimethyl sulfoxide, dimethyl thiourea) to inhibit the 5-ASA/Fe-mediated oxidative reactions. Maximum hydroxyl radical formation was achieved at a 5-ASA-to-Fe3+ ratio of 1.0 (20 microM 5-ASA and 20 microM Fe3+). Increasing this ratio significantly inhibited OH. formation with a concomitant reduction in lipid peroxidation and deoxyribose degradation. Finally, we demonstrated that 5-ASA promotes the reductive release of Fe3+ from ferritin. Data obtained in this study suggest that 5-ASA may, under certain conditions, promote the formation of potentially injurious free radical species. These oxidative reactions may contribute to some of the adverse side effects known to be associated with the newer preparations of 5-ASA. PMID: 1505290, UI: 92371110 Med Hypotheses 1998 Mar;50(3):239-51 A chelate theory for the mechanism of action of aspirin-like drugs. Wang X Department of Pathology, Cornell University Medical College, New York, Two hundred years after the discovery of the pharmaceutical usefulness of aspirin, it and aspirin-like drugs, a family with an
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Response:
"Pssst asked: If flaming is a kind of "defense mechanism" against diabetes, is it done consciously or instinctively?
Depends on what specie of Flamebirds you’re talking about.
Response:
– Hide quoted text — Show quoted text – made me stop and think. Could the personal attacks on this NG, which would at first appear to be harmful, actually have some positive effect? Could it be that all the hard feelings, the obsessive flaming and counter flaming keep us agitated, depressed, and so queasy that we easily keep our appetites under control? Could it be that the behavior on this newsgroup, thought to be unusually confrontational, combative, and rancorous (just showing off the vocab—these are all pretty much synonymous), serves to keep its participants healthy? By the way, don’t know if you know this, but I’ve seen this newsgroup being discussed on other newsgroups. The upshot of the discussion was that if you like Jerry Springer, you should tune in to MHD. Research has already proven it .. I spoke to it before where researchers found a tribe in the mountains who would fly off the handle at the slightest little thing .. They narrowed the problem down to a blood sugar problem.. The anger would raise their blood sugar levels .. Over on the arthritis list they are now ‘in a huddle’ discussing how to mass email my ISP .. to have me pulled from my server ..
What a wonderful result that would be, but strangely, I think embarking on actions like that are almost as childish as someone without diabetes posting on this NG. – Hide quoted text — Show quoted text – They have nothing ‘on me’ to do it ..but they are now pulling postings out of the groups to mass email with them .. and I suppose a couple of the scraps out of this group are going out .. All because I again refuse to back down to threats and abuse .. and the ‘religious’ fanatics who are attacking me because of my sig .. Sulpha drugs .. used by EVERYONE and doing great things in those with arthritis .. are the latest .. They found after all these years they work by chelating the iron in the body .. You would think they might ‘thank me’ for ‘pointing it out’ but instead these guys are crying ‘blue bloody murder’ and writing fake abuse letters to my server who has already been inundated with letters over the past few months ..
That should give you a bit of an idea that your posts aren’t exactly top of the "must read" list for the majority of posters watchtwat. Hell these guys have been yelling the f world at me for awhile .. I simply say ‘why would you try to have a guys ISP pull him when he places articles like these’ ..
Because it’s crap?? And I think it is definitely the religious fanatics who are really going nuts .. cause THEY know He was no vegetarian and the fact that what I say about iron
Iron! I knew it couldn’t last Beav
Response:
I don’t know about others, O.L., but when I get depressed, I eat. On the other hand, maybe the flamers get the opposite effect. Whenever I watch Animal Planet, they’re always showing some weird things that animals do. These weird things are often "defense mechanisms" to keep the species alive. For example, one species of bird will fly around wildly appearing to have a broken wing. They do this to attract predators away from their nest. But I’ve always assumed that animals do these things instinctively. If flaming is a kind of "defense mechanism" against diabetes, is it done consciously or instinctively?
– Hide quoted text — Show quoted text – As an "offended lurker," I was going to post a long diatribe against all of the personal attacks here, when I read a post from a medical doctor that made me stop and think. Could the personal attacks on this NG, which would at first appear to be harmful, actually have some positive effect? Let me quote William Biggs, MD, a man who often brings light to the darkness on MHD. "…However you need to bear in mind that depression suppresses appetite, and if the world suddenly becomes a happier place, the appetite will improve. So relief of depressive symptoms may result in weight gain, and thus increase the risk of diabetes." Could it be that all the hard feelings, the obsessive flaming and counter flaming keep us agitated, depressed, and so queasy that we easily keep our appetites under control? Could it be that the behavior on this newsgroup, thought to be unusually confrontational, combative, and rancorous (just showing off the vocab—these are all pretty much synonymous), serves to keep its participants healthy? By the way, don’t know if you know this, but I’ve seen this newsgroup being discussed on other newsgroups. The upshot of the discussion was that if you like Jerry Springer, you should tune in to MHD.
Response:
made me stop and think. Could the personal attacks on this NG, which would at first appear to be harmful, actually have some positive effect? Could it be that all the hard feelings, the obsessive flaming and counter flaming keep us agitated, depressed, and so queasy that we easily keep our appetites under control? Could it be that the behavior on this newsgroup, thought to be unusually confrontational, combative, and rancorous (just showing off the vocab—these are all pretty much synonymous), serves to keep its participants healthy? By the way, don’t know if you know this, but I’ve seen this newsgroup being discussed on other newsgroups. The upshot of the discussion was that if you like Jerry Springer, you should tune in to MHD.
Research has already proven it .. I spoke to it before where researchers found a tribe in the mountains who would fly off the handle at the slightest little thing .. They narrowed the problem down to a blood sugar problem.. The anger would raise their blood sugar levels .. Over on the arthritis list they are now ‘in a huddle’ discussing how to mass email my ISP .. to have me pulled from my server .. They have nothing ‘on me’ to do it ..but they are now pulling postings out of the groups to mass email with them .. and I suppose a couple of the scraps out of this group are going out .. All because I again refuse to back down to threats and abuse .. and the ‘religious’ fanatics who are attacking me because of my sig .. Sulpha drugs .. used by EVERYONE and doing great things in those with arthritis .. are the latest .. They found after all these years they work by chelating the iron in the body .. You would think they might ‘thank me’ for ‘pointing it out’ but instead these guys are crying ‘blue bloody murder’ and writing fake abuse letters to my server who has already been inundated with letters over the past few months .. Hell these guys have been yelling the f world at me for awhile .. I simply say ‘why would you try to have a guys ISP pull him when he places articles like these’ .. And I think it is definitely the religious fanatics who are really going nuts .. cause THEY know He was no vegetarian and the fact that what I say about iron and arthritis being TRUE comes SECOND to that.. even IF .. kids are being saved years of relentless pain .. Now that is why I try to stay away from the religious people .. they simply seem not to care who they ‘hurt’ just that they make sure THEY are in charge .. Scary stuff … TEKTRAN IRON DEPOSITION IN THE JOINTS OF CHILDREN WITH JUVENILE RHEUMATOID ARTHRITIS Author(s): SHYPAILO ROMAN J ELLIS KENNETH J PEREZ MARIA ABRAMS STEVEN A Interpretive Summary: We wanted to develop an accurate and noninvasive way of determining the amount of iron deposited in the joints of patients with juvenile rheumatoid arthritis. Children with JRA often develop excess iron in their joints, so doctors need a way of monitoring the iron level, particularly when prescribing iron supplements for the common problem of anemia. However, the only method currently available is to take a biopsy. We adapted a machine called a gamma counter to measure the iron in eight patients’ joints after giving them an iron isotope by vein. Then we compared the results with the total amount of iron in their bodies, measured by a whole-body counter. We found that we had developed an accurate new way of measuring iron in these patients’ joints. We also found that six of the eight subjects had excess uptake of the iron isotope in their joints. That provided a signal that a preponderance of JRA patients are prone to have this problem, and clinicians should take special care to monitor them for it. Moreover, this is the first time a noninvasive way of performing this measurement has been available. Keywords: energy reproduction growth body composition women infants children water potassium bioelectrical impedance conductance bromide space lactating iron adipose tissue lipid motabolism beta-adrenergic receptor cell culture neutron activation nitrogen carbon calcium sodium chlorine phosphorus hormonal changes differentiation adipocyte hnrim021125 Contact: USDA/ARS CHILDREN’S NUTR 1100 BATES ST. HOUSTON TX 77030 FAX: (713)798-7130 TEKTRAN United States Department of Agriculture Agricultural Research Service Updated: 1999-01-16 It seems the idea of the treatment of iron has been around for a long time but the mode of opertion of these drugs have only been coming to light in the last decade.. And it seems iron .. is the mode of operation .. or more like .. chelation of iron .. Orv Hetil 1991 Jun 16;132(24):1317-21 [New salicylic acid derivatives in the treatment of inflammatory intestinal diseases]. [Article in Hungarian] Kovacs A Fovarosi Tanacs Balassa Janos Korhaz-Rendelointezet I. Belyogyaszati ostaly. Drug therapy for inflammatory bowel disease was limited for many years to sulfasalazine and some corticosteroids. Since the discovery that 5-aminosalicylic acid (5-ASA) is the active moiety of sulphasalazine in the treatment of chronic inflammatory bowel disease, several new drugs have been developed. These consist either of slow- or delayed-release formulations of plaint 5-ASA (mesalazin) or sulpha-free azo-compounds of 5-ASA. The varying bioavailabilities of the different formulations and compounds make it possible to use them alternatively in different clinical situations. A review of the literature is given and suggestions as to how the new drugs can be used in different diseases. Publication Types: * Review * Review, tutorial PMID: 1677465, UI: 91312731 Save the above report in [Macintosh] [Text] format Order documents on this page through Loansome Doc Dig Dis Sci 1992 Sep;37(9):1383-9 Prooxidant properties of 5-aminosalicylic acid. Possible mechanism for its adverse side effects. Grisham MB, Ware K, Marshall S, Yamada T, Sandhu IS Department of Physiology and Biophysics, Louisiana State University Medical Center, Shreveport 71130. There is a growing body of experimental and clinical evidence to suggest that oral or rectal administration of 5-ASA or 5-ASA conjugates is associated with significant adverse side effects including pancreatitis, hepatitis, and renal toxicity. The objective of this study was to assess the ability of 5-ASA to interact with low-molecular-weight iron to yield oxygen-derived free radicals and to determine whether these oxidants could damage model biological compounds. We found that 5-ASA was very effective at chelating ferric iron (Fe3+), and it rapidly reduced Fe3+ to the ferrous form (Fe2+). Addition of the 5-ASA/Fe2+ chelate to solutions containing polyunsaturated fatty acids or deoxyribose resulted in lipid peroxidation and oxidative carbohydrate degradation, respectively. These results are consistent with the formation of the highly reactive (and cytotoxic) hydroxyl radical. Formation of this free radical species was confirmed by the ability of hydroxyl radical scavengers (dimethyl sulfoxide, dimethyl thiourea) to inhibit the 5-ASA/Fe-mediated oxidative reactions. Maximum hydroxyl radical formation was achieved at a 5-ASA-to-Fe3+ ratio of 1.0 (20 microM 5-ASA and 20 microM Fe3+). Increasing this ratio significantly inhibited OH. formation with a concomitant reduction in lipid peroxidation and deoxyribose degradation. Finally, we demonstrated that 5-ASA promotes the reductive release of Fe3+ from ferritin. Data obtained in this study suggest that 5-ASA may, under certain conditions, promote the formation of potentially injurious free radical species. These oxidative reactions may contribute to some of the adverse side effects known to be associated with the newer preparations of 5-ASA. PMID: 1505290, UI: 92371110 Med Hypotheses 1998 Mar;50(3):239-51 A chelate theory for the mechanism of action of aspirin-like drugs. Wang X Department of Pathology, Cornell University Medical College, New York, Two hundred years after the discovery of the pharmaceutical usefulness of aspirin, it and aspirin-like drugs, a family with an ever-increasing number of members, are an indispensable part of modern life. However, the question as to how these drugs work in the body has remained unsettled. It is postulated here that this group of drugs may exert their therapeutic (and adverse) effects by chelating various physiologically important metallic cations in the body. The chelate theory is supported by the vast majority, if not all, of the observations on these drugs made in the past. Publication Types: * Review * Review, academic PMID: 9578329, UI: 98237440 Save the above report in [Macintosh] [Text]
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Response:
As an "offended lurker," I was going to post a long diatribe against all of the personal attacks here, when I read a post from a medical doctor that made me stop and think. Could the personal attacks on this NG, which would at first appear to be harmful, actually have some positive effect? Let me quote William Biggs, MD, a man who often brings light to the darkness on MHD. "…However you need to bear in mind that depression suppresses appetite, and if the world suddenly becomes a happier place, the appetite will improve. So relief of depressive symptoms may result in weight gain, and thus increase the risk of diabetes." Could it be that all the hard feelings, the obsessive flaming and counter flaming keep us agitated, depressed, and so queasy that we easily keep our appetites under control? Could it be that the behavior on this newsgroup, thought to be unusually confrontational, combative, and rancorous (just showing off the vocab—these are all pretty much synonymous), serves to keep its participants healthy? By the way, don’t know if you know this, but I’ve seen this newsgroup being discussed on other newsgroups. The upshot of the discussion was that if you like Jerry Springer, you should tune in to MHD.
Response:
Categories: Dyslexia Test | 
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Lucky it’s not Patty, at least a few years ago. They would had to put her in restraints. She would go into screaming hysterics at the sight of a needle. Today it’s not so bad. Seems a few years ago I hypnotized her daily for continued weight control. The first time, I gave her a post-hypnotic command that when I spoke a certain phrase to her, she would go under, instantly. From then on, whenever she had to have a blood test, I put her under at the first sign of panic. Worked like a charm. Today we don’t have to do that unless she’s really nervous about something already.